Human Sera
Cayman Chemical EfaroxnhydrochlorIde 50mg
An α2-AR (EC50s = 1 receptor antagonist; binds to α2A-, α2B-, and α2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively); binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion at 100 μM; binds to rat RIN-5AH insulinoma cell membranes (IC50g = 32 nM) and stimulates insulin secretion at 100 μM; lowers basal blood glucose levels in mice at 5 mg/kg; increases L-DOPA synthesis in rat cortex and hippocampus by 77 and 57%, respectively at 10 mg/kg
Cayman Chemical Chrysnthemum LInarIn 50mg
A flavonoid glycoside with diverse biological activities; potentiates TRAIL-induced cytotoxicity and apoptosis in U87MG human glioma cells; potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model; reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury from 12.5-50 mg/kg; inhibits AChE and induces dyskinesia recovery in a zebrafish model of Alzheimer's disease in tank water at 50 μg/ml
Cayman Chemical -5 7-DImethyltocol 50mg
A form of tocopherol; has similar antioxidant activity to α-tocol, but lower activity than γ-tocol; increases microviscosity of PC rat liver liposomes by 70.6% when used at a molar ratio of 0.2 to PC; has been used as an internal standard for the quantification of tocols, tocopherols, and tocopheryl quinones by HPLC
Cayman Chemical SwertIamarIn 100mg
A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day
Cayman Chemical ButyrylLcarnItInchlorIde 100mg
A butyrate ester of carnitine; blocks carnitine uptake by the carnitine transporter and glycine transport by the amino acid transporter in HRPE cells (IC50s = 1.5 µM and 4.6 mM, respectively)
Cayman Chemical Mangostn 50mg
A xanthone with diverse biological activities: scavenges DPPH radicals in vitro (IC50 = 23.6 μM); is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively); inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages; macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes; inhibits carbon tetrachloride-induced increases in serum levels of AST and ALT and decreases in hepatic SOD2 activity and GSH content in a mouse model of liver fibrosis
Cayman Chemical FenpropathrIn 50mg
A pyrethroid insecticide; a slow activator of Nav1.8; decreases the number of Colorado potato beetle (L. decemlineata) adults and third stage larvae at 0.01%; has been found in watershed sediment samples
Cayman Chemical AzasetronhydrochlorIde 50mg
An orally bioavailable 5-HT3 antagonist (Ki = 2.9 nM); selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 μM for both), as well as D1, D2, α1-, and α2-adrenergic receptors (IC50s = >10 μM); binds to H1 receptors (IC50 = 4.4 μM); inhibits 5-HT-induced contractions in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06); inhibits cisplatin-induced emesis in dogs and doxorubicin/cyclophosphamide-induced emesis in ferrets at 1 mg/kg
Cayman Chemical GInkgonlIc AcId 100mg
An anacardic acid with diverse biological activities; inhibits GPDH (IC50 = 3 μg/ml); inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM); reduces S. mutans biofilm formation (MBIC50 = 4 μg/ml)
Cayman Chemical ntIlImIcInsulfate 50mg
An aminoglycoside antibiotic; active against S. aureus, N. gonorrhoeae, E. coli, P. mirabilis, and P. aeruginosa (MICs = 0.4, 3.1, 0.8, 1.6, and 0.4 UG/ml, respectively) as well as Enterococci, Enterobacter, Citrobacter, and Klebsiella species (MICs = 3.1, 0.4, 0.8, and ≤0.2 UG/ml, respectively); induces nephrotoxicity in rats at 50-150 mg/kg; induces neuromuscular block in isolated diaphragm and soleus muscles in rabbits (ED50s = 18.5 and 62.2 mg/kg, respectively)
Cayman Chemical FentIconazolenItrate 100mg
An antimicrobial imidazole; active against clinical isolates of Candida species (MICs = 0.12-32 μg/ml); active against clinical isolates of bacteria associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria associated with skin infections (MICs = ≤0.03->16 μg/ml); inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically)
Cayman Chemical AcetamIprId 50mg
A neonicotinoid insecticide; an agonist of insect nAChRs; activates nAChRs containing N. lugens α1 and rat β2 subunits (EC50 = 67 µM in X. laevis oocytes); leads to sexual and aggressive behaviors in adult male offspring after administration to pregnant mice (1 mg/kg); decreases anxiety-like behavior of adult male offspring in the light-dark transition test (1 and 10 mg/kg)
Cayman Chemical SGC0946trIfluoROCTAte sal 50mg
A DOT1L inhibitor (IC50 = 0.3 nM); selective for DOT1L over a panel of 12 additional protein methyltransferases, DNMT1, and a panel of 29 receptors and ion channels; reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 = 8.8 nM); selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 µM; adoptive transfer of isolated human CD3+ T cells pre-incubated with SGC0946 (0.5 µM) prevents weight loss, increases survival, and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
Cayman Chemical Polygala tnufola Tnugn 100mg
A triterpenoid sapogenin; inhibits IL-1β and ROS production from LPS-induced mouse BV2 microglia at 4 μM; decreases NLRP3 inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced mouse model of Parkinson’s disease at 25 mg/kg per day; reduces increases in lung edema and BALF IL-1β and TNF-α levels in a mouse model of intranasal S. aureus-induced pneumonia at 2 mg/kg