Human Sera
Cayman Chemical ComplnatusIde 50mg
A DHODH inhibitor (IC50 20 nM) selective for DHODH over a panel of greater than 400 kinases at 100 nM induces differentiation of ER-HoxA9 U937 and THP-1 cells in vitro (ED50s 1 UM) induces differentiation of tumor cells and reduces tumor growth in a THP-1 mouse xenograft model at 15 mg/kg three times daily or 5 mg/kg per day induces differentiation of bone marrow leukemic cells and increases survival In a retroviral transduction mouse model of HoxA9 Meis1 AML
Cayman Chemical -5 7-DImethyltocol 50mg
A diacylglycerol containing stearic acid and palmitic acid has been used to delay drug release in a hydrophilic medium
Cayman Chemical ForsythosIde B 50mg
A selective Nav1 1 and Nav1 3 channel blocker (IC50s 10000 nM for Nav1 1 Nav1 3 Nav1 4 and Nav1 5-1 8 respectively) induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1 3 channels at 1 M substitution of the Nav1 3 VSD4 with the Nav1 5 VSD4 reduces potency by 500-fold
Cayman Chemical EthopropazInhydrochlorIde 50mg
A cationic cholesterol a component of liposomes used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model cytotoxic to B16-F10 cells when used in liposomes at lipid concentrations greater than 20 UM a component of a DOPE-containing lipocomplex used to deliver DNA into mouse lung via intratracheal injection and to deliver VEGF siRNA into A431 and MDA-MB-231 cells
Cayman Chemical PnaxatrIol 100mg
A type II pyrethroid insecticide prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system reduces survival of ticks in vitro (1-1 5 mg) reduces survival of lice in sheep fleece and prevents re-infestation in contact-challenged sheep (5 and 10 ppm) induces developmental neurotoxicities in zebrafish (50 to 200 g/L) induces Parkinsons disease-like neurodegeneration in rats (15 mg/kg twice weekly for 24 weeks)
Cayman Chemical DIroxImel Fumarate 50mg
A cytotoxic indole alkaloid cytotoxic to HepG2 A375 MDA-MB-231 SH-SY5Y and CT26 cells (IC50s 20 Ug/ml) cytostatic to wild-type S cerevisiae and cytotoxic to rad3-e5 and rad6-1 mutant S cerevisiae
Cayman Chemical DnshensusodIum salt 100mg
A cholesterol ester with anticancer activity inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells at 50 and 150 M respectively an ionizable anionic detergent commonly used to stabilize unilamellar vesicles and liposomes has been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs antibiotics and oligonucleotides and to solubilize various proteins as well as erythrocyte ghosts
Cayman Chemical 4NItrophenyl aLrhamnopyrn 50mg
An internal standard for the quantification of probenecid by GC- or LC-MS
Cayman Chemical -Indoxacarb 50mg
A selective and reversible proton pump inhibitor inhibits gastric H /K ATPase (IC50 17 nM) does not inhibit porcine Na /K ATPase activity (10 UM) maintains its inhibitory effect in weakly acidic and neutral pH conditions (IC50s 19 and 28 nM respectively) inhibits histamine-stimulated acid secretion in a dose-dependent manner in rats (1 2 and 4 mg/kg) inhibits acid secretion for more than 48 hours in dogs (0 1 to 1 mg/kg)
Cayman Chemical DIlInoelaIdIn 50mg
A peptide hormone that lowers blood calcium level and inhibits bone resorption binds to hCTR2 with IC50 values of 0 933 0 224 0 134 and 0 317 nM alone and with RAMP1 2 or 3 respectively induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 0 166 nM) inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 0 003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 33 9 mg/kg)
Cayman Chemical ACTAmInophen GlucuronIdSo 50mg
An esterified form of pentadecanoic acid has been found as a minor component in biodiesels made from the transesterification of beef tallow soybean oil and babassu oil blends has been found in latent fingerprint residue samples
Cayman Chemical DItrIdecnoIn 100mg
A peptide vasoconstrictor ligand for ETA and ETB (Kbs 32 8 and 1 33 nM respectively) inducesBarrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s 8 75 and 8 55 respectively) induces vasoconstriction in isolated rat mesenteric arterial beds (ED50 90 8 pmol) induces contraction of isolated rat uteri restores vasoconstriction of vessels at the follicular apex of the ovarian follicle and ovulation in Amhr2cre/ mice
Cayman Chemical GHK-Cuacetate 100mg
An inhibitor of FGFR1 (IC50 40 nM) selective for FGFR1 over PDGFB and EGFR (IC50s 262 and 3700 nM respectively) inhibits constitutive phosphorylation of FGFR1 in Sf9 insect cells overexpressing human FGFR1 and in A121 ovarian carcinoma cells inhibits growth of A121 cells in a time-dependent manner
Cayman Chemical DecnoIc AcId-d19 100mg
A derivative of latanoprost and an isomer of latanoprost ethyl amide
Cayman Chemical PentagastrIn 100mg
An endogenous peptide with diverse biological activities a selective agonist of NPR2 and 3 (Kds 7 10 8 and 500000 pM for NPR2 3 and 1 respectively) stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 2 2 nM) and relaxes isolated rat cerebral arterioles (EC50 0 52 nM) (25 g/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock (25 g/kg)